This talk summarises the impacts of the lived experience and how they affect the recruitment of patients to scientific trials and biobanking of clinical samples. To effectively develop cures for chronic hepatitis B, liver tissue must be studied. However, the invasive collection of this material lies in tension with many patient aspects. Chronic Hepatitis B acts as a particularly salient example of psychosocial impacts affecting research biases given the asymptomatic nature of the condition, and the stigma and discrimination that accompanies it. This talk will also discuss potential solutions that encourage patient/researcher partnership.